A chromosomally abnormal embryo will never result in a normal pregnancy or it may result a pregnancy loss. PGD is a method which identifies the genetically normal embryos thereby increases the pregnancy rate.
What is PGD?
Preimplantation Genetic Diagnosis, is an advanced genetics test used to study the chromosomes of the embryo. It can improve a woman’s chance of a baby being born with a normal chromosomes.
It increases the pregnancy rate, reduces pregnancy loss and increases live births. .
How Is It Done?
After routineICSI and embryo development ,on the day 3 of the embryo development ,each cell is usually representative of all cells from that particular embryo. One of the cells of the embryo is removed with the use of microsurgical techniques. The selected cell is analysed by a technique called FISH (fluorescence in situ hybridization) to identify the chromosomes of the cell.In the meantime, during PGD, the embryos develop undisturbed in an incubator.
The embryo with the normal chromosomes are selected and implanted in the uterus. This procedure gives a better pregnancy rate as the genetically normal embryos are chosen for implantation.
Are there risks to the embryo?
It does not have any effect on the normal development of the embryo. The removal of one cell does not reduce the ability of the embryo to implant .
Which patients stand to benefit from PGD?
Single Gene Disorders
The term single gene disorder refers to any one of the hundreds of inherited diseases caused by mutation (change) in a single gene.
How likely is it that i may be affected by a chromosome abnormality?
50% of embryos from women who are 35 to 39 have chromosomal abnormalities. For those over 40, the percentages increase to 80% or higher.
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How would PGD improve my chances?
PGD can double the chance of implantation of the embryo,
reduce pregnancy loss as much as three-fold,
and increase the likelihood of live births.